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KMID : 0043320080310070866
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Archives of Pharmacal Research
2008 Volume.31 No. 7 p.866 ~ p.871
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Antifibrotic Activity of Diterpenes from Biota orientalis Leaves on Hepatic Stellate Cells
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Lee Mi-Kyeong
Yang Hye-Kyung
Yoon Jeong-Seon
Jeong Eun-Ju
Kim Do-Yoon
Ha Na-Ry
Sung Sang-Hyun
Kim Young-Choong
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Abstract
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Antifibrotic effect of twelve diterpenes (1-12) from the 90% methanolic fraction of Biota orientalis leaves was evaluated employing HSC-T6 cells by assessing cell proliferation and morphological change. Among these diterpenes, totarol (8) and isopimara-8(14),15-dien-19-oic acid (9) dramatically reduced cell proliferation in dose- and time-dependent manner. Furthermore, treatment with these compounds resulted in the different pattern of morphological changes of HSC-T6 cells. Taken together, antiproliferative activity of diterpenes from B. orientalis might suggest therapeutic potentials against liver fibrosis.
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KEYWORD
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Diterpene, Biota orientalis, HSC-T6, Hepatic stellate cells, Hepatic fibrosis
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